Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

نویسندگان

  • Nikaïa Smith
  • Nicolas Pietrancosta
  • Sophia Davidson
  • Jacques Dutrieux
  • Lise Chauveau
  • Pasquale Cutolo
  • Michel Dy
  • Daniel Scott-Algara
  • Bénédicte Manoury
  • Onofrio Zirafi
  • Isabelle McCort-Tranchepain
  • Thierry Durroux
  • Françoise Bachelerie
  • Olivier Schwartz
  • Jan Münch
  • Andreas Wack
  • Sébastien Nisole
  • Jean-Philippe Herbeuval
چکیده

Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mouse model of influenza infection. We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by amines to inhibit pDC. Our study establishes a functional link between natural amines and the innate immune system and identifies CXCR4 as a potential 'on-off' switch of pDC activity with therapeutic potential.

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عنوان ژورنال:

دوره 8  شماره 

صفحات  -

تاریخ انتشار 2017